Co-stimulation is critical to the function of chimeric antigen receptor (CAR) T-cells.Previously, we demonstrated that dual co-stimulation can be effectively harnessed by a parallel (p)CAR architecture in which a CD28-containing second generation CAR is co-expressed with a 4-1BB containing chimeric co-stimulatory receptor (CCR).When compared to lin
The cloud-based computer-aided engineering (CAE) technology expands the application scope of CAE, solves the problem of Combination Wheelchairs uneven distribution, and improves the efficiency of the simulation resources.Consequently, various industries are turning to cloud CAE technology to design their products.However, to utilize this technology
Recently, scientists have been interested in developing advanced techniques for technological applications razor blade using sustainable biochar (BC) materials.In this study, poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, PEDOT/PSS, was doped with 5 wt.% and 10 wt.% of Activated biochar (A-BC) obtained from Chlorophyta (green Algae) using
Although transcatheter aortic valve implantation (TAVI) has revolutionised the landscape of treatment for aortic stenosis, there exists a cohort of patients where TAVI is deemed futile.Among the pivotal high-risk trials, one-third to half of patients either died or received no symptomatic benefit from the procedure at 1 year.Futility of TAVI result
INTRODUCTION The temporomandibular joint is a synovial, complex (hinge-sliding) joint that connects the temporal bone with the mandible by means of an articular disc.Temporomandibular joint dysfunctions most often concern several disease entities and include various symptoms and ailments.One of the first symptoms of the disease is pain that stems C